Hydrochloric Acid → Ethyl butyrimidate hydrochloride

HRID 963446Notes

Reaction equation

HRID 963446 reaction equation
[C:1](#[N:5])[CH2:2][CH2:3][CH3:4].[ClH:6].[CH3:7][CH2:8][OH:9]>>[ClH:6].[CH2:8]([O:9][C:1](=[NH:5])[CH2:2][CH2:3][CH3:4])[CH3:7]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 8008Butyronitrile

Product 1

HCID 12235055Ethyl butyrimidate hydrochlorideYield 48%

Procedure

A solution of butyronitrile (15 g, 0.21 mol) in EtOH (150 mL) was cooled in an ice bath. The cold solution was then saturated with hydrogen chloride. The reaction mixture was refrigerated for 18 hours. The ethanol was evaporated under vacuum. The residual oily substance was then treated with ether to obtain the title compound (15.5 g, 48% yield) which was used in the next reaction.

Workup

  1. customThe ethanol was evaporated under vacuum
  2. additionThe residual oily substance was then treated with ether

Sources & evidence

ORD record
ord-bde062dac4ca495b97d32afa6b60f22e
Source dataset
uspto-grants-1998_06
Patent number
US05763473

Reaction notes

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