7-(2-Aminoethyl)-4-hydroxy-1,3-benzothiazol-2(3H)-one hydrobromide → HCID 19082113, compound

HRID 963572Notes

Reaction equation

HRID 963572 reaction equation
Br.[NH2:2][CH2:3][CH2:4][C:5]1[C:13]2[S:12][C:11](=[O:14])[NH:10][C:9]=2[C:8]([OH:15])=[CH:7][CH:6]=1.[N+:16]([C:19]1[CH:24]=[CH:23][C:22]([CH2:25][CH2:26][O:27][CH2:28][CH2:29][S:30]([CH2:33][CH2:34][C:35](O)=[O:36])(=[O:32])=[O:31])=[CH:21][CH:20]=1)([O-:18])=[O:17]>>[OH:15][C:8]1[C:9]2[NH:10][C:11](=[O:14])[S:12][C:13]=2[C:5]([CH2:4][CH2:3][NH:2][C:35](=[O:36])[CH2:34][CH2:33][S:30]([CH2:29][CH2:28][O:27][CH2:26][CH2:25][C:22]2[CH:21]=[CH:20][C:19]([N+:16]([O-:18])=[O:17])=[CH:24][CH:23]=2)(=[O:31])=[O:32])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 138142707-(2-Aminoethyl)-4-hydroxy-1,3-benzothiazol-2(3H)-one hydrobromideHCID 19082175HCID 19082175, compound

Product 1

HCID 19082113HCID 19082113, compound

Procedure

Following the general method outlined in Example 20c) using 7-[2-aminoethyl]-4-hydroxy-1,3-benzothiazol-2(3H)-one hydrobromide and 3-[2-[2-[4-nitrophenyl]-ethoxy]ethylsulphonyl]propanoic acid [Example 13a)]gave the subtitled compound after purification by chromatography over silica using 8% ethanol in dichloromethane as eluant.

Sources & evidence

ORD record
ord-e58f1543447549c99d242696615a8dbe
Source dataset
uspto-grants-1998_06
Patent number
US05763465

Reaction notes

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