HuagongsheHuagongshe Chemistry Print Report · For research reference only
7-(2-Aminoethyl)-4-hydroxy-1,3-benzothiazol-2(3H)-one hydrobromide → N-[2-[4-Hydroxy-2-oxo-3H-1,3-benzothiazol-7-yl]ethyl]-3-[2-[2-[4-nitrophenyl]ethoxy]ethylsulphonyl]propanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 7-(2-Aminoethyl)-4-hydroxy-1,3-benzothiazol-2(3H)-one hydrobromide | HCID 13814270 | — |
| Reactant | 3-[2-[2-[4-Nitrophenyl]ethoxy]ethylsulphonyl]propanoic acid | HCID 19082175 | — |
| Product | N-[2-[4-Hydroxy-2-oxo-3H-1,3-benzothiazol-7-yl]ethyl]-3-[2-[2-[4-nitrophenyl]ethoxy]ethylsulphonyl]propanamide | HCID 19082113 | — |
Reaction Steps
Following the general method outlined in Example 20c) using 7-[2-aminoethyl]-4-hydroxy-1,3-benzothiazol-2(3H)-one hydrobromide and 3-[2-[2-[4-nitrophenyl]-ethoxy]ethylsulphonyl]propanoic acid [Example 13a)]gave the subtitled compound after purification by chromatography over silica using 8% ethanol in dichloromethane as eluant.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05763465 |
| Source dataset | uspto-grants-1998_06 |
| ORD ID | ord-e58f1543447549c99d242696615a8dbe |
| Source note | uspto-grants-1998_06 |