HCID 22375350, compound → HCID 22407312, compound

HRID 963624Notes

Reaction equation

HRID 963624 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9]2[C:14]([Cl:15])=[CH:13][C:12]([C:16]([F:19])([F:18])[F:17])=[CH:11][N:10]=2)=[CH:4][C:3]=1[N:20]1[C:25](=[O:26])[N:24]([CH3:27])[C:23](=[O:28])[N:22]([CH2:29][C:30]([O:32]C(C)(C)C)=[O:31])[C:21]1=[O:37]>FC(F)(F)C(O)=O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9]2[C:14]([Cl:15])=[CH:13][C:12]([C:16]([F:18])([F:19])[F:17])=[CH:11][N:10]=2)=[CH:4][C:3]=1[N:20]1[C:25](=[O:26])[N:24]([CH3:27])[C:23](=[O:28])[N:22]([CH2:29][C:30]([OH:32])=[O:31])[C:21]1=[O:37]

Participants

3

Reactant 1

HCID 22375350HCID 22375350, compound

Product 1

HCID 22407312HCID 22407312, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of tert-butyl 3-{2-bromo-5-{[3-chloro-5-(trifluoromethyl)-2-pyridyl]oxy}phenyl}tetrahydro-5-methyl-2,4,6-trioxo-s-triazine-1(2H)-acetate (7.00 g, 0.012 mol) in trifluoroacetic acid (40 mL) is refluxed for 2.5 hours, cooled to room temperature and concentrated in vacuo to give the title product which is identified by 1HNMR spectral analysis.

Workup

  1. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-6a4f66ea013c49a4bdf42df5b00f2c3d
Source dataset
uspto-grants-1998_06
Patent number
US05763605

Reaction notes

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