HCID 86752759, compound → HCID 86752758, compound

HRID 963640Notes

Reaction equation

HRID 963640 reaction equation
[SH:1][C:2]1[C:3]([P:15]([OH:18])(=[O:17])[OH:16])([P:11]([OH:14])(=[O:13])[OH:12])[CH:4]=[C:5]2[C:10]=1[NH:9][CH2:8][CH:7]=[CH:6]2>O=[Pt]=O.O>[SH:1][CH:2]1[CH:10]2[CH:5]([CH2:6][CH2:7][CH2:8][NH:9]2)[CH2:4][C:3]1([P:15]([OH:18])(=[O:16])[OH:17])[P:11]([OH:13])(=[O:12])[OH:14]

Participants

4

Reactant 1

HCID 86752759HCID 86752759, compound

Product 1

HCID 86752758HCID 86752758, compound

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 962WaterSolvent

Procedure

Dihydro-7-mercapto-1-pyrindine-6,6-bisphosphonic acid (0.5 mmol) [prepared as described in Example A hereinbefore], distilled water (100 ml) and PtO2 (0.5 g) are placed in a 500 ml Parr hydrogenation bottle. The mixture is hydrogenated at room temperature (40 psi) for 48 hours. The solution is filtered through celite and washed with hot water. The filtrate is then concentrated under reduced pressure and the desired product is obtained in good purity by further drying the resultant solid overnight under vacuum.

Workup

  1. customis hydrogenated at room temperature
  2. customfor 48 hours
  3. filtrationThe solution is filtered through celite
  4. washwashed with hot water
  5. concentrationThe filtrate is then concentrated under reduced pressure

Sources & evidence

ORD record
ord-f9fece480c2c496694c7ee4b331b01f3
Source dataset
uspto-grants-1998_06
Patent number
US05763611

Reaction notes

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