HCID 19083171, compound → HCID 19083148, compound

HRID 963668Notes

Reaction equation

HRID 963668 reaction equation
C([NH:5][S:6]([C:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][C:16]=2[F:18])[N:11]([CH3:19])[N:10]=1)(=[O:8])=[O:7])(C)(C)C>FC(F)(F)C(O)=O>[CH3:19][N:11]1[C:12]2[C:17](=[C:16]([F:18])[CH:15]=[CH:14][CH:13]=2)[C:9]([S:6]([NH2:5])(=[O:8])=[O:7])=[N:10]1

Participants

3

Reactant 1

HCID 19083171HCID 19083171, compound

Product 1

HCID 19083148HCID 19083148, compoundYield 86.8%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent2×

Procedure

15 g (53 mmol) of 3-(N-t-butylsulfamoyl)-1-methyl-4-fluoro-1H-indazole was added to 50 ml of trifluoroacetic acid, and the mixture was stirred overnight. After completion of the reaction, trifluoroacetic acid was distilled off under reduced pressure, and the residue was washed with n-hexane to obtain 10.5 g (yield: 86.8%) of 1-methyl-4-fluoro-1H-indazole-3-sulfonamide (slightly purple crystals). Melting point: 221°-223° C.

Workup

  1. distillationwas distilled off under reduced pressure
  2. washthe residue was washed with n-hexane

Sources & evidence

ORD record
ord-665d10a6d248464a89bacd803c6be7f7
Source dataset
uspto-grants-1998_06
Patent number
US05763616

Reaction notes

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