反应详情

温度

110 °C

Sodium hydride (60% dispersion in mineral oil, 0.528 g) was added to dry ethanol (20 ml), N-{3-chloro-1-methyl-3-[4-(trifluoromethyl)phenyl]prop-2-enylidene}-N-methylmethanaminium hexafluorophosphate (intermediate 34, 2.8 g) was added followed by ethyl thioglycolate (0.79 g) and the mixture heated at 110° C. for 2 hours under nitrogen. The cooled mixture was concentrated in vacuo and the residue partitioned between water and diethyl ether. The organic layer was collected, dried over magnesium sulphate and concentrated to give the title compound as a brown solid.

1. additionwas added
2. concentrationThe cooled mixture was concentrated in vacuo
3. customthe residue partitioned between water and diethyl ether
4. customThe organic layer was collected
5. dry with materialdried over magnesium sulphate
6. concentrationconcentrated