HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → 1-(2-Fluoro-2-(methoxycarbonyl)ethenyl)-1-(3,4-methylenedioxyphenyl)cyclopropane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Methyl 2,2-dichloro-2-fluoroacetate | HCID 13612258 | — |
| Reactant | 5-Cyclopropyl-1,3-benzodioxole | HCID 16205050 | — |
| Catalyst | Zinc | HCID 23994 | — |
| Catalyst | Cuprous chloride | HCID 62652 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-(2-Fluoro-2-(methoxycarbonyl)ethenyl)-1-(3,4-methylenedioxyphenyl)cyclopropane | HCID 53809022 | 51% |
Reaction Steps
The method of Example 1 was repeated using zinc powder (2.94 g), copper (I) chloride (0.45 g) molecular sieve 4A (3 g), tetrahydrofuran (54 ml), 1-formyl-1-(3,4-methylenedioxyphenylcyclopropane (3.09 g), acetic anhydride (1.5 ml) and methyl dichlorofluoroacetate (2.36 g) to yield the title compound (2.2 g, 51%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05763700 |
| Source dataset | uspto-grants-1998_06 |
| ORD ID | ord-26e31d36616544a6a4f400ba8636a8e6 |
| Source note | uspto-grants-1998_06 |