Benzene → 1-(3-Acetoxy-2-fluoroprop-1-enyl)-1-(2,4-difluorophenyl)cyclopropane

HRID 963823Notes

Reaction equation

HRID 963823 reaction equation
[C:1](Cl)(=[O:3])[CH3:2].[F:5][C:6]1[CH:11]=[C:10]([F:12])[CH:9]=[CH:8][C:7]=1[C:13]1([CH:16]=[C:17]([F:20])[CH2:18][OH:19])[CH2:15][CH2:14]1.C1C=CC=CC=1>N1C=CC=CC=1>[C:1]([O:19][CH2:18][C:17]([F:20])=[CH:16][C:13]1([C:7]2[CH:8]=[CH:9][C:10]([F:12])=[CH:11][C:6]=2[F:5])[CH2:14][CH2:15]1)(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 241BenzeneHCID 6367Acetyl chlorideHCID 542319431-(2,4-Difluorophenyl)-1-(2-fluoro-3-hydroxyprop-1-enyl)cyclopropane

Product 1

HCID 542493411-(3-Acetoxy-2-fluoroprop-1-enyl)-1-(2,4-difluorophenyl)cyclopropaneYield 92%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

The method of Example 17 was repeated using acetyl chloride (0.46 ml), 1-(2,4-difluorophenyl)-1-(2-fluoro-3-hydroxyprop-1-enyl)cyclopropane (Example 15) (0.21 g), benzene (12 ml) and pyridine (0.09 ml) to yield the title compound (0.22 g, 92%).

Sources & evidence

ORD record
ord-9e53db628f1f4e5ba5524be5026ecc66
Source dataset
uspto-grants-1998_06
Patent number
US05763700

Reaction notes

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