4-Bromobenzaldehyde → HCID 9839602, compound

HRID 963919Notes

Reaction equation

HRID 963919 reaction equation
[CH3:1][C:2]1([CH3:15])[CH2:11][CH2:10][C:9]([CH3:13])([CH3:12])[C:8]2[CH:7]=[C:6]([OH:14])[CH:5]=[CH:4][C:3]1=2.Br[C:17]1[CH:24]=[CH:23][C:20]([CH:21]=[O:22])=[CH:19][CH:18]=1>>[CH3:1][C:2]1([CH3:15])[CH2:11][CH2:10][C:9]([CH3:13])([CH3:12])[C:8]2[CH:7]=[C:6]([O:14][C:17]3[CH:24]=[CH:23][C:20]([CH:21]=[O:22])=[CH:19][CH:18]=3)[CH:5]=[CH:4][C:3]1=2

Participants

3

Reactant 2

HCID 707414-BromobenzaldehydeHCID 2687865,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-ol

Product 1

HCID 9839602HCID 9839602, compound

Procedure

In a manner similar to Example 1(a) above, by the reaction of 5.3 g (15 mmol) of 5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthol with 3.1 g (16.5 mmol) of 4-bromobenzaldehyde, 2.4 g of the expected aldehyde of melting point 75°-6° C. were obtained after purification by chromatography on a silica column eluted with a mixture of dichloromethane and hexane (50/50).

Workup

  1. customwere obtained
  2. customafter purification by chromatography on a silica column
  3. washeluted with a mixture of dichloromethane and hexane (50/50)

Sources & evidence

ORD record
ord-01ee6714c50d48369e27d96e5642daf0
Source dataset
uspto-grants-1998_06
Patent number
US05766610

Reaction notes

Loading…