Water → HCID 9929845, compound

HRID 963922Notes

Reaction equation

HRID 963922 reaction equation
[CH2:1]([NH2:3])[CH3:2].[CH3:4][C:5]1[C:6]([S:19][C:20]2[CH:28]=[CH:27][C:23]([C:24](Cl)=[O:25])=[CH:22][CH:21]=2)=[CH:7][C:8]2[C:9]([CH3:18])([CH3:17])[CH2:10][CH2:11][C:12]([CH3:16])([CH3:15])[C:13]=2[CH:14]=1.O>C1COCC1>[CH2:1]([NH:3][C:24](=[O:25])[C:23]1[CH:22]=[CH:21][C:20]([S:19][C:6]2[C:5]([CH3:4])=[CH:14][C:13]3[C:12]([CH3:15])([CH3:16])[CH2:11][CH2:10][C:9]([CH3:18])([CH3:17])[C:8]=3[CH:7]=2)=[CH:28][CH:27]=1)[CH3:2]

Participants

5

Reactant 3

HCID 962WaterHCID 6341EthylamineHCID 22117430HCID 22117430, compound

Product 1

HCID 9929845HCID 9929845, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

640 μl (8 mmol) of a 70% solution of ethylamine and 20 ml of THF were introduced into a round-bottomed flask. A solution of 735 mg (2 mmol) of 4-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthylthio)benzoyl chloride dissolved in 30 ml of THF was added dropwise and the mixture was stirred at room temperature for three hours. The reaction medium was poured into water, extracted with ethyl acetate, the organic phase decanted off, dried over magnesium sulfate and evaporated.

Workup

  1. additionwas added dropwise
  2. extractionextracted with ethyl acetate
  3. customthe organic phase decanted off
  4. dry with materialdried over magnesium sulfate
  5. customevaporated

Sources & evidence

ORD record
ord-3dfaf3558209491f9d6e28477b10a9f2
Source dataset
uspto-grants-1998_06
Patent number
US05766610

Reaction notes

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