反应详情

温度

0 °C

4,4-Diphenyl-1-butanol (22.41 g, 0.099 mol) was dissolved in ether (250 mL). CBr4 (41.07 g, 0.123 mol) was added and the reaction cooled to 0° C. Triphenylphosphine (38.96 g, 0.148 mol) in ether (400 mL) was added dropwise to the reaction. The reaction was then allowed to warm to room temperature overnight. DMSO (3.51 mL) was added, and the reaction allowed to stir for 8 hours. The white precipitate was filtered and washed with ether (100 mL). The ether was removed in vacuo, and the residue washed with hexanes and filter. The hexanes were removed in vacuo, and the residue chromatographed on silica gel eluting with hexanes to give 20.72 g (72%) of desired product as an oil.

1. temperatureto warm to room temperature overnight
2. filtrationThe white precipitate was filtered
3. washwashed with ether (100 mL)
4. customThe ether was removed in vacuo
5. washthe residue washed with hexanes
6. filtrationfilter
7. customThe hexanes were removed in vacuo
8. customthe residue chromatographed on silica gel eluting with hexanes