関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ethyl Acetate | HCID 8857 | — |
| 反応物 | Isoquinolin-5-ol | HCID 30386 | — |
| 反応物 | 1,1-Diphenyl-4-bromobutane | HCID 12223458 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2-(4,4-Diphenylbutyl)-5-hydroxyisoquinolinium bromide | HCID 15870893 | 69.6% |
反応手順
A mixture of 5-hydroxyisoquinoline (2.17 g, 14.95 mmol) and 1-bromo-4,4-diphenylbutane (4.79 g, 16.56 mmol) in 75 mL of anhydrous DMF was stirred at 80° C. for 16 hours. The reaction mixture was cooled to room temperature. Ethyl acetate (200 mL) was added to precipitate product. The solid was collected by filtration and washed with ethyl acetate (1×70 mL). The solid was air-dried to give 4.52 g of product as an off-white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05767129 |
|---|
| 出典データセット | uspto-grants-1998_06 |
|---|
| ORD ID | ord-cdcbb52ef3a04fea8042aa5de75d6e0d |
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| 出典メモ | uspto-grants-1998_06 |
|---|
