反应详情

温度

80 °C

A mixture of 5-hydroxyisoquinoline (2.17 g, 14.95 mmol) and 1-bromo-4,4-diphenylbutane (4.79 g, 16.56 mmol) in 75 mL of anhydrous DMF was stirred at 80° C. for 16 hours. The reaction mixture was cooled to room temperature. Ethyl acetate (200 mL) was added to precipitate product. The solid was collected by filtration and washed with ethyl acetate (1×70 mL). The solid was air-dried to give 4.52 g of product as an off-white solid.

1. temperatureThe reaction mixture was cooled to room temperature
2. customto precipitate product
3. filtrationThe solid was collected by filtration
4. washwashed with ethyl acetate (1×70 mL)
5. customThe solid was air-dried