反应详情

温度

80 °C

A mixture of 5-hydroxyisoquinoline (4.56 g, 31.41 mmol) and 4,4-bis(4-fluorophenyl)butyl bromide (11.40 g, 35.06 mmol. Prepared according to the procedure of Miroslav Rajsner, et al., Czech. Collect. Czech. Chem. Commun., 1978;43:1760) in 100 mL of anhydrous DMF was stirred at 80° C. overnight. The reaction mixture was cooled to 0° C. Ethyl acetate (400 mL) was added to precipitate product. The solid was collected by filtration and washed with ethyl acetate (2×100 mL). The solid was air-dried to give 10.74 g of product as an off-white solid.

1. customPrepared
2. customCollect
3. temperatureThe reaction mixture was cooled to 0° C
4. additionEthyl acetate (400 mL) was added
5. customto precipitate product
6. filtrationThe solid was collected by filtration
7. washwashed with ethyl acetate (2×100 mL)
8. customThe solid was air-dried