Isoquinolin-5-ol → 2-[4,4-Bis-(4-fluorophenyl)butyl]-5-hydroxyisoquinolinium bromide

Participants

Reaction Conditions

Reaction Steps

A mixture of 5-hydroxyisoquinoline (4.56 g, 31.41 mmol) and 4,4-bis(4-fluorophenyl)butyl bromide (11.40 g, 35.06 mmol. Prepared according to the procedure of Miroslav Rajsner, et al., Czech. Collect. Czech. Chem. Commun., 1978;43:1760) in 100 mL of anhydrous DMF was stirred at 80° C. overnight. The reaction mixture was cooled to 0° C. Ethyl acetate (400 mL) was added to precipitate product. The solid was collected by filtration and washed with ethyl acetate (2×100 mL). The solid was air-dried to give 10.74 g of product as an off-white solid.

Provenance & Evidence