Water → 6-Bromo-3H-oxazolo(4,5-b)pyridin-2-one

HRID 964013Notes

Reaction equation

HRID 964013 reaction equation
[O:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[NH:3][C:2]1=[O:10].[Br:11]Br.O>CN(C)C=O>[Br:11][C:7]1[CH:8]=[C:9]2[O:1][C:2](=[O:10])[NH:3][C:4]2=[N:5][CH:6]=1

Participants

5

Reactant 3

HCID 962WaterHCID 24408BromineHCID 2799900Oxazolo(4,5-b)pyridin-2(3H)-one

Product 1

HCID 136144586-Bromo-3H-oxazolo(4,5-b)pyridin-2-one

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

After dissolving oxazolo[4,5-b]pyridin-2(3H)-one (5 g, 23.25 mmol) in N,N-dimethylformamide (100 ml), bromine (1.28 ml, 25.58 mmol) is slowly added. Stirring is maintained at room temperature for 2 hours. Water (50 ml) is then added to the reaction mixture; the title product is isolated after having been filtered, rinsed with a little water and dried in vacuo. The yield obtained is 90%. ##STR22##

Workup

  1. additionis slowly added

Sources & evidence

ORD record
ord-f92e552118f44ec594f49b9b5170dc04
Source dataset
uspto-grants-1998_06
Patent number
US05767128

Reaction notes

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