HCID 15379646, compound → 3-CYANOMETHYL-6-ACETYLOXAZOLO[4,5-b]PYRIDIN-2(3H)-ONE

HRID 964018Notes

Reaction equation

HRID 964018 reaction equation
Br[C:2]1[CH:3]=[C:4]2[O:10][C:9](=[O:11])[N:8]([CH2:12][C:13]#[N:14])[C:5]2=[N:6][CH:7]=1.BrC1[CH:17]=[C:18]2[O:24]C(=O)N(C)C2=NC=1>>[C:13]([CH2:12][N:8]1[C:5]2=[N:6][CH:7]=[C:2]([C:18](=[O:24])[CH3:17])[CH:3]=[C:4]2[O:10][C:9]1=[O:11])#[N:14]

Participants

3

Reactant 2

HCID 15379646HCID 15379646, compoundHCID 159260166-Bromo-3-methyl[1,3]oxazolo[4,5-b]pyridin-2(3H)-one

Product 1

HCID 190792953-CYANOMETHYL-6-ACETYLOXAZOLO[4,5-b]PYRIDIN-2(3H)-ONE

Procedure

The method of operation is the same as that used for the synthesis of the compound of Example 1 (coupling with 1-ethoxy-1-(trimethylstannyl)ethylene). 6-bromo-3-(cyanomethyl)oxazolo[4,5-b]pyridin-2(3H)-one from Preparation 3 is used instead of the 6-bromo-3-methyloxazolo[4,5-b]pyridin-2(3H)-one from Preparation 2. The yield obtained is 60%. ##STR48##

Workup

  1. customThe yield obtained

Sources & evidence

ORD record
ord-a01f0868a0fe4eea9d39c856b25f7060
Source dataset
uspto-grants-1998_06
Patent number
US05767128

Reaction notes

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