Diatrizoate → Potassium 3,5-diacetylamino-2,4,6-triiodobenzoate

HRID 964370Notes

Reaction equation

HRID 964370 reaction equation
[C:1]([NH:4][C:5]1[C:6]([I:20])=[C:7]([C:11]([I:19])=[C:12]([NH:15][C:16](=[O:18])[CH3:17])[C:13]=1[I:14])[C:8]([OH:10])=[O:9])(=[O:3])[CH3:2].[OH-].[K+:22]>O>[C:16]([NH:15][C:12]1[C:11]([I:19])=[C:7]([C:6]([I:20])=[C:5]([NH:4][C:1](=[O:3])[CH3:2])[C:13]=1[I:14])[C:8]([O-:10])=[O:9])(=[O:18])[CH3:17].[K+:22]

Participants

4

Reactant 2

HCID 2140DiatrizoateHCID 14797Potassium Hydroxide3×

Product 1

HCID 23692364Potassium 3,5-diacetylamino-2,4,6-triiodobenzoate

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Conditions

Temperature
60 °C

Procedure

A suspension of 3,5-diacetylamino-2,4,6-triiodobenzoic acid (0.5 g, 0.81 mmol) in water (5 ml) was heated to 60° C. and an aqueous solution of KOH prepared by dissolving KOH (46 mg, 0.81 mmol) in water (2 ml) was added. A solution of 0.5N KOH was added dropwise to the suspension to adjust it to pH 7. Water was removed under reduced pressure to give a residue which was washed twice with ethanol and dried under reduced pressure.

Workup

  1. additionwas added
  2. customWater was removed under reduced pressure
  3. customto give a residue which
  4. washwas washed twice with ethanol
  5. customdried under reduced pressure

Sources & evidence

ORD record
ord-afa61595c8bc4318979fa7570452e007
Source dataset
uspto-grants-1998_06
Patent number
US05767299

Reaction notes

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