Potassium Carbonate → HCID 21937189, compound

HRID 964447Notes

Reaction equation

HRID 964447 reaction equation
[C:1]([C:4]1[CH:18]=[CH:17][C:7]([O:8][CH2:9][CH2:10][CH2:11][C:12]([O:14]CC)=[O:13])=[CH:6][C:5]=1[F:19])(=[O:3])[CH3:2].C(=O)([O-])[O-].[K+].[K+]>CO.O>[C:1]([C:4]1[CH:18]=[CH:17][C:7]([O:8][CH2:9][CH2:10][CH2:11][C:12]([OH:14])=[O:13])=[CH:6][C:5]=1[F:19])(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 86752385HCID 86752385, compound

Product 1

HCID 21937189HCID 21937189, compoundYield 82%

Reagents, catalysts & solvents 1

HCID 22242641Methanol--water (1/1)Solvent

Procedure

4-(4-Acetyl-3-fluorophenoxy)butanoic acid, ethyl ester (20 mg, 0.0745 mmol) is dissolved in 1 mL of methanol/water (3:2) and treated with 30.91 mg (0.22 mmol) of potassium carbonate according to the procedure described for Example 4 to give 14 mg (82%) of 4-(4-acetyl-3-fluorophenoxy)butanoic acid as a white powder: m.p. 110°-111° C.; The 1H NMR (300 MHz, CDCl3) is consistent with the desired product; IR (KBr) 1710, 1670, 1610 cm-1 ; MS m/e calculated for C12H13 O4FNa: 263.0695, found 263.0699.

Sources & evidence

ORD record
ord-36ffbb6b46804ba28741b39d8e416286
Source dataset
uspto-grants-1998_06
Patent number
US05767285

Reaction notes

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