Potassium Carbonate → (2-Acetylphenoxy)butanoic acid

HRID 964449Notes

Reaction equation

HRID 964449 reaction equation
[C:1]([C:4]1[CH:18]=[CH:17][CH:16]=[CH:15][C:5]=1[O:6][CH:7]([CH2:13][CH3:14])[C:8]([O:10]CC)=[O:9])(=[O:3])[CH3:2].C(=O)([O-])[O-].[K+].[K+]>CO.O>[C:1]([C:4]1[CH:18]=[CH:17][CH:16]=[CH:15][C:5]=1[O:6][CH:7]([CH2:13][CH3:14])[C:8]([OH:10])=[O:9])(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 15741884(2-Acetylphenoxy)butanoic acid, ethyl ester

Product 1

HCID 15741852(2-Acetylphenoxy)butanoic acidYield 93%

Reagents, catalysts & solvents 1

HCID 22242641Methanol--water (1/1)Solvent

Procedure

(2-Acetylphenoxy)butanoic acid, ethyl ester (500 mg, 2.00 mmol) is dissolved in 3 mL of methanol/water (3:2) and treated with 828 mg (5.99 mmol) of potassium carbonate according to the procedure described for Example 4 to give 412 mg (93%) of (2-acetylphenoxy)butanoic acid as a white powder. The 1H NMR (300 MHz, CDCl3) is consistent with the desired product; IR (KBr) 1710, 1670, 1590 cm-1 ; MS m/e calculated for C12H15O4 : 223.0970, found 223.0971.

Sources & evidence

ORD record
ord-e50a03502b09410d9310acda55af3534
Source dataset
uspto-grants-1998_06
Patent number
US05767285

Reaction notes

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