Acetonitrile → 2-Methylquinazoline

HRID 964569Notes

Reaction equation

[NH2:1][C:2]1[CH:15]=[CH:14][CH:13]=[CH:12][C:3]=1[C:4](C1C=CC=CC=1)=O.[C:16](#[N:18])[CH3:17]>>[CH3:17][C:16]1[N:18]=[CH:4][C:3]2[C:2](=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:1]=1

Participants

Reactant 2

HCID 6342Acetonitrile

HCID 760802-Aminobenzophenone

Product 1

HCID 5889872-Methylquinazoline

Procedure

In this method, 2-aminobenzophenone derivative (IV) is reacted with acetonitrile to yield 2-methylquinazoline derivative (IX), which is then brominated to 2-bromomethylquinazoline derivative (II-4). The reaction of compound (IV) and acetonitrile is carried out in the same manner as method D. Bromination of compound (IX) is carried out in the same manner as the bromination of compound (VII) by method C.

Sources & evidence

ORD record: ord-e51706796601477f9a062c3250903ba2
Source dataset: uspto-grants-1998_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05770602

Reaction notes

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