Sodium Carbonate → HCID 22449418, compound

HRID 964647Notes

Reaction equation

HRID 964647 reaction equation
[C:1]([NH:4][CH:5]1[CH2:14][C:13]2[C:8](=[C:9]([NH:17]C(=O)C)[CH:10]=[CH:11][C:12]=2[O:15][CH3:16])[C:7](=[O:21])[CH2:6]1)(=[O:3])[CH3:2].C(=O)([O-])[O-].[Na+].[Na+]>Cl>[C:1]([NH:4][CH:5]1[CH2:14][C:13]2[C:8](=[C:9]([NH2:17])[CH:10]=[CH:11][C:12]=2[O:15][CH3:16])[C:7](=[O:21])[CH2:6]1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 10340Sodium CarbonateHCID 86750958HCID 86750958, compound

Product 1

HCID 22449418HCID 22449418, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Conditions

Temperature
60 °C

Procedure

102 mg of the compound prepared in (4) above was charged into 20 ml of 3N hydrochloric acid aqueous solution, and the mixture was heated at 60° C. for 2 hours while stirring. After cooling to 0° C., the reaction mixture was neutralized with sodium carbonate and extracted with chloroform. The extract was dried over magnesium sulfate, and subjected to silica gil column chromatograghy using an chloroform-methanol (40:1) mixed solvent as an eluant to obtain fractions containing the target compound. The fractions were concentrated to produce 66 mg of the title compound.

Workup

  1. temperatureAfter cooling to 0° C.
  2. extractionextracted with chloroform
  3. dry with materialThe extract was dried over magnesium sulfate
  4. additionmixed solvent as an eluant
  5. customto obtain fractions
  6. additioncontaining the target compound
  7. concentrationThe fractions were concentrated

Sources & evidence

ORD record
ord-c24c5e779fa34655a2e4ade9160debe7
Source dataset
uspto-grants-1998_06
Patent number
US05770605

Reaction notes

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