Acetic Acid → HCID 22449479, compound

HRID 964658Notes

Reaction equation

HRID 964658 reaction equation
[C:1]([NH:4][C:5]1[CH:6]=[CH:7][C:8](Cl)=[C:9]2[C:14]=1[C:13](=O)[C:12](=CO)[CH2:11][CH2:10]2)(=[O:3])[CH3:2].[C:19](O)(=O)C.[ClH:23].[NH2:24][OH:25]>O>[C:1]([NH:4][C:5]1[CH:6]=[CH:7][C:8]([Cl:23])=[C:9]2[C:14]=1[C:13]1[CH:19]=[N:24][O:25][C:12]=1[CH2:11][CH2:10]2)(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 443297Hydroxyamine hydrochlorideHCID 70156897HCID 70156897, compound

Product 1

HCID 22449479HCID 22449479, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
120 °C

Procedure

1.29 gm of the compound prepared in (1) above was dissolved into 30 ml of acetic acid. After the addition of 339 mg of hydroxylamine hydrochloride, the mixture was heated for 10 minutes at 120° C. while stirring. After cooling, water was added to collect the precipitate by filtration. The precipitate was washed with water and hexane to obtain 1.1 gm of the title compound.

Workup

  1. temperatureAfter cooling
  2. customto collect the precipitate
  3. filtrationby filtration
  4. washThe precipitate was washed with water and hexane

Sources & evidence

ORD record
ord-0beeab49c46246eebecde5f24bf2b434
Source dataset
uspto-grants-1998_06
Patent number
US05770605

Reaction notes

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