2,8-Diacetylamino-1-tetralone → HCID 22449464, compound

HRID 964664Notes

Reaction equation

HRID 964664 reaction equation
C(C1CCC2C(=C(C(=O)C)C=CC=2[C:14]#[N:15])C1=O)(=O)C.[C:20]([NH:23][CH:24]1[CH2:33][CH2:32][C:31]2[C:26](=[C:27]([NH:34]C(=O)C)[CH:28]=[CH:29][CH:30]=2)[C:25]1=[O:38])(=[O:22])[CH3:21]>>[C:20]([NH:23][CH:24]1[CH2:33][CH2:32][C:31]2[C:26](=[C:27]([NH2:34])[CH:28]=[CH:29][C:30]=2[C:14]#[N:15])[C:25]1=[O:38])(=[O:22])[CH3:21]

Participants

3

Reactant 2

HCID 120472982,8-Diacetylamino-1-tetraloneHCID 22449413HCID 22449413, compound

Product 1

HCID 22449464HCID 22449464, compound

Procedure

The reaction was carried out in the same manner as in Example 1-(4), except that 250 mg of the compound prepared in (1) above was used instead of 2,8-diacetylamino-1-tetralone of Example 1-(4), and post-treated to produce 182 mg of the title compound. IRνmaxKBr cm-1 : 3428, 3336, 2216, 1652, 1614, 1542; NMR(CDCl3)δ: 1.6-2.0(1H, m), 2.09(3H, s), 2.56-3.39(3H, m), 4.51-4.71(1H, m), 6.59(1H, d, J=9.0 Hz), 7.40(1H, d, J=9.0 Hz); MASS m/z: 243(M+)

Workup

  1. additionpost-treated

Sources & evidence

ORD record
ord-d29e863a8b714e53a2d7fe60910de025
Source dataset
uspto-grants-1998_06
Patent number
US05770605

Reaction notes

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