反应详情

温度

10 °C

4 g of 2-amino-4-methylamino-6-chloropyrimidine are suspended in 50 ml of ethanol. After having cooled to 10° C., 11.9 g of meta-chloroperbenzoic acid are added dropwise as a solution in 100 ml of ethanol. At the end of addition, room temperature is regained and stirring is continued for 3 hours. The reaction mixture is cooled to 5° C. and then filtered on sintered glass. The precipitate obtained is recrystallized from 160 ml of a 2/3-1/3 ethanol-water mixture. 1.60 g of 2-amino-4-methylamino-6-chloropyrimidine 3-oxide are obtained.

1. additionAt the end of addition, room temperature
2. temperatureThe reaction mixture is cooled to 5° C.
3. filtrationfiltered on sintered glass
4. customThe precipitate obtained
5. customis recrystallized from 160 ml of a 2/3-1/3 ethanol-water mixture