反应详情

3.4 g of 2-amino-4-methylamino-6-chloropyrimidine 3-oxide are suspended in 70 ml of ethanol. 4.15 g of pyrrolidine are added. The reaction mixture is refluxed for 7 hours. After it has returned to room temperature, 1.30 g of potassium hydroxide are added as an 85% solution in 15 ml of ethanol. After 1 hour's stirring the mixture is filtered on paper. The filtrates are evaporated to dryness. The residue obtained is recrystallized from 50 ml of a 9/1 acetonitrile-water mixture. 2.40 g of 2-amino-4-methylamino-6-pyrrolidinopyrimidine 3-oxide are obtained.

1. temperatureThe reaction mixture is refluxed for 7 hours
2. customhas returned to room temperature
3. filtrationis filtered on paper
4. customThe filtrates are evaporated to dryness
5. customThe residue obtained
6. customis recrystallized from 50 ml of a 9/1 acetonitrile-water mixture