Tert-Butylamine → HCID 19073890, compound

HRID 964846Notes

Reaction equation

HRID 964846 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[C:4](Cl)[N:3]=1.[C:10]([NH2:14])([CH3:13])([CH3:12])[CH3:11]>C(O)C>[NH2:1][C:2]1[N:3]=[C:4]([NH:14][C:10]([CH3:13])([CH3:12])[CH3:11])[CH:5]=[C:6]([Cl:8])[N:7]=1

Participants

4

Reactant 2

HCID 6385Tert-ButylamineHCID 655222-Amino-4,6-dichloropyrimidine

Product 1

HCID 19073890HCID 19073890, compoundYield 75.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

10 g of 2-amino-4,6-dichloropyrimidine are suspended in 100 ml of ethanol. 44.50 g of tert-butylamine are added. The reaction mixture is refluxed for 48 hours. It is evaporated to dryness. The residue is taken up in 50 ml of water. The mixture is stirred for 1 hour and the precipitate is then filtered off on sintered glass. It is recrystallized from 60 ml of a 50/50 ethanol-water mixture. 9.25 g of 2-amino-4-tert-butylamino-6-chloro-pyrimidine are obtained.

Workup

  1. temperatureThe reaction mixture is refluxed for 48 hours
  2. customIt is evaporated to dryness
  3. filtrationthe precipitate is then filtered off on sintered glass
  4. customIt is recrystallized from 60 ml of a 50/50 ethanol-water mixture

Sources & evidence

ORD record
ord-29e44f8b4727462982e7717f2fd6a3b3
Source dataset
uspto-grants-1998_06
Patent number
US05772990

Reaction notes

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