反应详情

8 g of 2-amino-4-ethylamino-6-chloropyrimidine are suspended in 150 ml of ethanol. 21.80 g of meta-chloroperbenzoic acid are added dropwise as solution in 150 ml of ethanol. After 2 hours' stirring, the reaction mixture is concentrated to a third in a rotary evaporator. The precipitate is filtered off on sintered glass, washed with 2×50 ml of ethyl ether and is then recrystallized from 60 ml of a 9/1 acetonitrile-ethanol mixture. 3.05 g of 2-amino-4-ethylamino-6-chloropyrimidine 3-oxide are obtained.

1. concentrationthe reaction mixture is concentrated to a third in a rotary evaporator
2. filtrationThe precipitate is filtered off on sintered glass
3. washwashed with 2×50 ml of ethyl ether
4. customis then recrystallized from 60 ml of a 9/1 acetonitrile-ethanol mixture