Potassium Carbonate → HCID 54453132, compound

HRID 964893Notes

Reaction equation

HRID 964893 reaction equation
[CH:1]([C:3]1[CH:17]=[CH:16][C:6]([O:7][CH2:8][CH2:9][CH2:10][C:11]([O:13]CC)=[O:12])=[C:5]([N+:18]([O-:20])=[O:19])[CH:4]=1)=[O:2].C(=O)([O-])[O-].[K+].[K+]>CO.O>[CH:1]([C:3]1[CH:17]=[CH:16][C:6]([O:7][CH2:8][CH2:9][CH2:10][C:11]([OH:13])=[O:12])=[C:5]([N+:18]([O-:20])=[O:19])[CH:4]=1)=[O:2]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 86752383HCID 86752383, compound

Product 1

HCID 54453132HCID 54453132, compoundYield 69.1%

Reagents, catalysts & solvents 1

HCID 22242641Methanol--water (1/1)Solvent

Procedure

4-(4-Formyl-2-nitrophenoxy)butanoic acid, ethyl ester (135 mg, 0.48 mmol) is dissolved in 3 mL of methanol/water (3:2) and treated with 232 mg (1.68 mmol) of potassium carbonate according to the procedure described for Example 4 to give 84 mg (69%) of 4-(4-formyl-2-nitrophenoxy)butanoic acid as a yellow powder: m.p. 136°-139°; the 1H NMR (300 MHz, CDCl3) is consistent with the desired product; IR (KBr) 3400, 1730, 1700, 1650, 1600, 1570 cm-1 ; MS (CI) m/e 254, 236, 224, 208, 196, 168.

Sources & evidence

ORD record
ord-8d014279fb964be9b906f4af31bfdae7
Source dataset
uspto-grants-1998_06
Patent number
US05773001

Reaction notes

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