HRID9649

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11776

Triphenylphosphine

C18H15P

结构：COC(=O)c1cc(-c2ccc(C(F)(F)F)cc2)oc1CBr

HCID21986318

未命名化合物

2 次

PRODUCTS

生成物

结构：COC(=O)c1cc(-c2ccc(C(F)(F)F)cc2)oc1C[P+](c1ccccc1)(c1ccccc1)c1ccccc1.[Br-]

HCID86593915

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID1140

Toluene

C7H8

PROCEDURE

实验过程

Methyl 2-bromomethyl-5-[4-(trifluoromethyl)phenyl]-3-furoate (intermediate 44, 0.20 g) was dissolved in toluene (3 ml) treated with triphenylphosphine (0.159 g) and heated to reflux for 1 hour. The reaction was allowed to cool and the white precipitate was collected by filtration, washed with fresh toluene to give the title compound as a white powder.

WORKUP

后处理

temperatureheated
temperatureto reflux for 1 hour
temperatureto cool
filtrationthe white precipitate was collected by filtration
washwashed with fresh toluene

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f6ddaba673be4decb2b45330286d6069
来源数据集: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07091237B2
来源说明: uspto-grants-2006_08

反应 SMILES

[Br:1][CH2:2][C:3]1[O:4][C:5]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][CH:13]=2)=[CH:6][C:7]=1[C:8]([O:10][CH3:11])=[O:9].[C:22]1([P:28]([C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>C1(C)C=CC=CC=1>[Br-:1].[CH3:11][O:10][C:8]([C:7]1[CH:6]=[C:5]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][CH:13]=2)[O:4][C:3]=1[CH2:2][P+:28]([C:29]1[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=1)([C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1)[C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1)=[O:9]