Hydrochloric Acid → HCID 178487721, compound

HRID 964991Notes

Reaction equation

HRID 964991 reaction equation
[OH:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:12][CH3:13])=[CH:9][CH:10]=2)[N:5]=[CH:4][C:3]=1[C:14]([O:16]CC)=[O:15].Cl>[OH-].[Na+]>[OH:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:12][CH3:13])=[CH:9][CH:10]=2)[N:5]=[CH:4][C:3]=1[C:14]([OH:16])=[O:15]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178469633HCID 178469633, compound

Product 1

HCID 178487721HCID 178487721, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

Ethyl 4-hydroxy-7-methoxy-3-quinolinecarboxylate (24.7 g, 0.1 mol) was hydrolysed with 2N aqueous solution of sodium hydroxide (250 ml) through boiling for 2 hours. The reaction mixture was allowed to cool to room temperature and adjusted with 2N hydrochloric acid to pH 5. The resulting precipitates were collected by filtration and washed with water. The precipitates were dried at 100°-120° C. for 3 hours in an oven and further dried under reduced pressure overnight over calcium chloride to obtain 21.4 g (98%) of 4-hydroxy-7-methoxy-3-quinolinecarboxylic acid.

Workup

  1. customThe resulting precipitates
  2. filtrationwere collected by filtration
  3. washwashed with water
  4. customThe precipitates were dried at 100°-120° C. for 3 hours in an oven
  5. dry with materialfurther dried under reduced pressure overnight over calcium chloride

Sources & evidence

ORD record
ord-4b3725cf12eb45ff8525b8aae5323214
Source dataset
uspto-grants-1998_06
Patent number
US05773449

Reaction notes

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