Water → HCID 70197194, compound

HRID 965009Notes

Reaction equation

HRID 965009 reaction equation
[SH:1][C:2]1[NH:6][C:5]2[CH:7]=[CH:8][CH:9]=[CH:10][C:4]=2[N:3]=1.[ClH:11].[Cl:12][CH2:13][C:14]1[C:19]([O:20][CH3:21])=[C:18]([S:22][CH2:23][CH2:24][CH2:25][Cl:26])[CH:17]=[CH:16][N:15]=1.O>C(O)(C)C>[ClH:12].[ClH:11].[Cl:26][CH2:25][CH2:24][CH2:23][S:22][C:18]1[CH:17]=[CH:16][N:15]=[C:14]([CH2:13][S:1][C:2]2[NH:6][C:5]3[CH:7]=[CH:8][CH:9]=[CH:10][C:4]=3[N:3]=2)[C:19]=1[O:20][CH3:21]

Participants

5

Reactant 3

HCID 962WaterHCID 22117351HCID 22117351, compoundHCID 178527775HCID 178527775, compound

Product 1

HCID 70197194HCID 70197194, compoundYield 67%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

2-Mercapto-1H-benzimidazole (10 g) and 2-chloromethyl-4-(3-chloropropylthio)-3-methoxypyridine hydrochloride (1 equivalent) are stirred in 150 ml of isopropanol and 15 ml of water at 80° C. for 5 hours, the mixture is cooled and the solid which has precipitated out is filtered off and recrystallized from isopropanol/water. The title compound is obtained as a pale brown powder; melting point 117°-119° C. (decomposition); yield: 67% of theory.

Workup

  1. temperaturethe mixture is cooled
  2. customthe solid which has precipitated out
  3. filtrationis filtered off
  4. customrecrystallized from isopropanol/water

Sources & evidence

ORD record
ord-d15945d815a64d7484672e8b18599a15
Source dataset
uspto-grants-1998_06
Patent number
US05773451

Reaction notes

Loading…