Methyl iodide → 3-(3-Cyclopropylmethoxy-1,2,5-thiadiazol-4-yl)-1-methylpyridinium iodide

HRID 965041Notes

Reaction equation

HRID 965041 reaction equation
[CH3:1][I:2].[CH:3]1([CH2:6][O:7][C:8]2[C:12]([C:13]3[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=3)=[N:11][S:10][N:9]=2)[CH2:5][CH2:4]1>CC(C)=O>[I-:2].[CH:3]1([CH2:6][O:7][C:8]2[C:12]([C:13]3[CH:14]=[N+:15]([CH3:1])[CH:16]=[CH:17][CH:18]=3)=[N:11][S:10][N:9]=2)[CH2:4][CH2:5]1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 190752393-(3-Cyclopropylmethoxy-1,2,5-thiadiazol-4-yl)pyridine

Product 1

HCID 190754673-(3-Cyclopropylmethoxy-1,2,5-thiadiazol-4-yl)-1-methylpyridinium iodide

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture of methyl iodide (0.25 ml, 4 mmol) and 3-(3-cyclopropylmethoxy-1,2,5-thiadiazol-4yl)pyridine (400 mg, 1.7 mmol) in acetone (5 ml) was stirred at room temperature for 36 h. The title compound precipitated from the solution and was collected by filtration to yield 0.41 g (65%).

Workup

  1. customThe title compound precipitated from the solution
  2. filtrationwas collected by filtration
  3. customto yield 0.41 g (65%)

Sources & evidence

ORD record
ord-cd8d90f37b504f20a9f632b425c85986
Source dataset
uspto-grants-1998_06
Patent number
US05773452

Reaction notes

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