反应详情

5-Ethylisatin (70 g), acetic acid (200 ml) and concentrated sulfuric acid (0.8 ml) were charged in a 500 ml two-necked flask, followed by stirring at room temperature. Then, 50 ml of aqueous 30% hydrogen peroxide was added dropwise and, after stirring at 60° to 65° C. for additional one hour, the mixture was cooled. The deposited solid was filtered, washed with water and dried under vacuum to obtain 6-ethylisatoic anhydride. Crude yield: 35 g

1. stirringafter stirring at 60° to 65° C. for additional one hour
2. temperaturethe mixture was cooled
3. filtrationThe deposited solid was filtered
4. washwashed with water
5. customdried under vacuum