反应详情

In step 1, compound (41) is dissolved in methanol and treated with a methanolic solution of sodium methylate at room temperature, whereby the cyclization of the substituents on the imidazole ring of compound (41) occurs. This ring-forming reaction may be conducted in the same manner as in the step 18 of SYNTHETIC PROCESS CHART (A). Thus, 3-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-6,7-dihydroimidazo[4,5-d][1,3]diazepin-8(3H)-one [Compound (42)] is produced.

1. customThis ring-forming reaction