Sodium Methoxide → HCID 178516779, compound

HRID 965382Notes

Reaction equation

HRID 965382 reaction equation
C[O-].[Na+].NC[C:6]([C:8]1[N:9]=[CH:10][N:11]([C@@H:18]2[O:23][C@H:22]([CH2:24][OH:25])[C@@H:20]([OH:21])[C@@H:19]2[F:26])[C:12]=1[N:13]=[CH:14][N:15](C)[CH3:16])=[O:7]>CO>[F:26][C@H:19]1[C@H:20]([OH:21])[C@@H:22]([CH2:24][OH:25])[O:23][C@H:18]1[N:11]1[C:12]2[N:13]=[CH:14][NH:15][CH2:16][C:6](=[O:7])[C:8]=2[N:9]=[CH:10]1

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 537945214-aminoacetyl-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-(dimethylaminomethyleneamino)imidazole2×

Product 1

HCID 178516779HCID 178516779, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In step 1, compound (41) is dissolved in methanol and treated with a methanolic solution of sodium methylate at room temperature, whereby the cyclization of the substituents on the imidazole ring of compound (41) occurs. This ring-forming reaction may be conducted in the same manner as in the step 18 of SYNTHETIC PROCESS CHART (A). Thus, 3-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-6,7-dihydroimidazo[4,5-d][1,3]diazepin-8(3H)-one [Compound (42)] is produced.

Workup

  1. customThis ring-forming reaction

Sources & evidence

ORD record
ord-38eb2e43429a4fbaae6d9808472f671a
Source dataset
uspto-grants-1998_06
Patent number
US05773607

Reaction notes

Loading…