HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Methoxide → HCID 178516779, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | 4-aminoacetyl-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-(dimethylaminomethyleneamino)imidazole | HCID 53794521 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 178516779 | HCID 178516779 | — |
Reaction Steps
In step 1, compound (41) is dissolved in methanol and treated with a methanolic solution of sodium methylate at room temperature, whereby the cyclization of the substituents on the imidazole ring of compound (41) occurs. This ring-forming reaction may be conducted in the same manner as in the step 18 of SYNTHETIC PROCESS CHART (A). Thus, 3-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-6,7-dihydroimidazo[4,5-d][1,3]diazepin-8(3H)-one [Compound (42)] is produced.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05773607 |
| Source dataset | uspto-grants-1998_06 |
| ORD ID | ord-38eb2e43429a4fbaae6d9808472f671a |
| Source note | uspto-grants-1998_06 |