Hydroxyamine hydrochloride → HCID 136015764, compound

Participants

Reaction Steps

To a suspension of 2-cyano-2-ethoxyimino-acetamide (112.8 g, 0.8 mol) and sodium bicarbonate (134.4 g, 1.6 mol) in water (258 mol), hydroxylamine hydrochloride (61.6 g, 0.88 mol) in water (86 ml) was added dropwise at 80° to 85° C. The mixture was stirred at the same temperature for 3 hrs., and then treated in the same procedure as described in Preparation example 5 to give 2-carboxy-2-ethoxyimino-acetamidoxime (122.5 g) as crystals containing 28.6% of brine. Practical yield: 122.5×0.286=87.5 g. Yield: 62.5%.

Provenance & Evidence