Hydroxyamine hydrochloride → HCID 136015764, compound

HRID 965415Notes

Reaction equation

HRID 965415 reaction equation
[C:1]([C:3](=[N:7][O:8][CH2:9][CH3:10])[C:4](N)=[O:5])#[N:2].C(=O)(O)[O-:12].[Na+].Cl.[NH2:17][OH:18]>O>[C:4]([C:3](=[N:7][O:8][CH2:9][CH3:10])[C:1](=[N:17][OH:18])[NH2:2])([OH:12])=[O:5]

Participants

5

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 540712282-Cyano-2-(ethoxyimino)acetamide

Product 1

HCID 136015764HCID 136015764, compoundYield 87.4%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

To a suspension of 2-cyano-2-ethoxyimino-acetamide (112.8 g, 0.8 mol) and sodium bicarbonate (134.4 g, 1.6 mol) in water (258 mol), hydroxylamine hydrochloride (61.6 g, 0.88 mol) in water (86 ml) was added dropwise at 80° to 85° C. The mixture was stirred at the same temperature for 3 hrs., and then treated in the same procedure as described in Preparation example 5 to give 2-carboxy-2-ethoxyimino-acetamidoxime (122.5 g) as crystals containing 28.6% of brine. Practical yield: 122.5×0.286=87.5 g. Yield: 62.5%.

Workup

  1. additionwas added dropwise at 80° to 85° C
  2. addition, and then treated in the same procedure
  3. customas described in Preparation example 5

Sources & evidence

ORD record
ord-1f8b883166504da3a477a98fdcecd85a
Source dataset
uspto-grants-1998_06
Patent number
US05773624

Reaction notes

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