Formic Acid → HCID 53708380, compound

HRID 965416Notes

Reaction equation

HRID 965416 reaction equation
[CH3:1][O:2][N:3]=[C:4]([C:9]1[N:13]=[C:12]([NH2:14])[S:11][N:10]=1)[C:5]([O:7][CH3:8])=[O:6].[CH:15](O)=[O:16]>>[CH3:1][O:2][N:3]=[C:4]([C:9]1[N:13]=[C:12]([NH:14][CH:15]=[O:16])[S:11][N:10]=1)[C:5]([O:7][CH3:8])=[O:6]

Participants

3

Reactant 2

HCID 284Formic AcidHCID 54508041HCID 54508041, compound

Product 1

HCID 53708380HCID 53708380, compoundYield 85%

Conditions

Temperature
70 °C

Procedure

Methyl 2-methoxyimino-2-(5-amino-1,2,4-thiadiazole-3-yl)-acetate (anti-isomer) (10 g, 0.046 mol) in 99% formic acid (50 g) was heated under stirring at 70° C. for 6 hrs. It was cooled to below 10° C. to separate crystals, which were collected by filtration, washed with methanol and dried to give methyl 2-methoxyimino-2-(5-formamido-1,2,4-thiadiazole-3-yl)-acetate (syn-isomer) (7.6 g, yield: 85%).

Workup

  1. temperatureIt was cooled to below 10° C.
  2. customto separate crystals, which
  3. filtrationwere collected by filtration
  4. washwashed with methanol
  5. customdried

Sources & evidence

ORD record
ord-a96cffa5859c4b36a341566384c99f88
Source dataset
uspto-grants-1998_06
Patent number
US05773624

Reaction notes

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