Formic Acid → HCID 53708380, compound

Participants

Reaction Conditions

Reaction Steps

Methyl 2-methoxyimino-2-(5-amino-1,2,4-thiadiazole-3-yl)-acetate (anti-isomer) (10 g, 0.046 mol) in 99% formic acid (50 g) was heated under stirring at 70° C. for 6 hrs. It was cooled to below 10° C. to separate crystals, which were collected by filtration, washed with methanol and dried to give methyl 2-methoxyimino-2-(5-formamido-1,2,4-thiadiazole-3-yl)-acetate (syn-isomer) (7.6 g, yield: 85%).

Provenance & Evidence