Formic Acid → HCID 54364803, compound

HRID 965418Notes

Reaction equation

HRID 965418 reaction equation
[F:1][CH2:2][O:3][N:4]=[C:5]([C:10]1[N:14]=[C:13]([NH2:15])[S:12][N:11]=1)[C:6]([O:8][CH3:9])=[O:7].[CH:16](O)=[O:17].C(OC(=O)C)(=O)C>>[F:1][CH2:2][O:3][N:4]=[C:5]([C:10]1[N:14]=[C:13]([NH:15][CH:16]=[O:17])[S:12][N:11]=1)[C:6]([O:8][CH3:9])=[O:7]

Participants

4

Reactant 3

HCID 284Formic AcidHCID 7918Acetic AnhydrideHCID 54214287HCID 54214287, compound

Product 1

HCID 54364803HCID 54364803, compoundYield 75.6%

Procedure

To a suspension of methyl 2-fluoromethoxyimino-2-(5-amino-1,2,4-thiadiazole-3-yl)-acetate (anti-isomer) (1.17 g, 5 mmol) in formic acid (1.38 g, 30 mmol), acetic anhydride (1.12 g, 10 mmol) was added. The mixture was treated in the same procedure as described in Example 9 to give methyl 2-fluoromethoxyimino-2-(5-formamido-1,2,4-thiadiazole-3-yl)-acetate (syn-isomer) (991 mg, yield: 73.8%).

Workup

  1. additionwas added
  2. additionThe mixture was treated in the same procedure

Sources & evidence

ORD record
ord-b2678f85f58d4fd7861bd654ad53c72a
Source dataset
uspto-grants-1998_06
Patent number
US05773624

Reaction notes

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