Formic Acid → HCID 53731397, compound

HRID 965422Notes

Reaction equation

HRID 965422 reaction equation
[CH2:1]([O:3][N:4]=[C:5]([C:10]1[N:14]=[C:13]([NH2:15])[S:12][N:11]=1)[C:6]([O:8][CH3:9])=[O:7])[CH3:2].[CH:16](O)=[O:17]>>[CH2:1]([O:3][N:4]=[C:5]([C:10]1[N:14]=[C:13]([NH:15][CH:16]=[O:17])[S:12][N:11]=1)[C:6]([O:8][CH3:9])=[O:7])[CH3:2]

Participants

3

Reactant 2

HCID 284Formic AcidHCID 53782355HCID 53782355, compound

Product 1

HCID 53731397HCID 53731397, compoundYield 49.6%

Conditions

Temperature
75 °C

Procedure

Methyl 2-ethoxyimino-2-(5-amino-1,2,4-thiadiazole-3-yl)-acetate (anti-isomer) (5.75 g, 25 mmol) in 99% formic acid (16.3 g) was heated under stirring at 75° C. for 6 hrs. The reaction mixture was treated in the same procedure as in Example 8 to give methyl 2-ethoxyimino-2-(5-formamido-1,2,4-thiadiazole-3-yl)-acetate (syn-isomer) (3.2 g, yield: 49.6%).

Workup

  1. additionThe reaction mixture was treated in the same procedure as in Example 8

Sources & evidence

ORD record
ord-16da24d9bbea49ba91df8ebae7b729be
Source dataset
uspto-grants-1998_06
Patent number
US05773624

Reaction notes

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