Formic Acid → HCID 53731397, compound

Participants

Reaction Conditions

Reaction Steps

Methyl 2-ethoxyimino-2-(5-amino-1,2,4-thiadiazole-3-yl)-acetate (anti-isomer) (5.75 g, 25 mmol) in 99% formic acid (16.3 g) was heated under stirring at 75° C. for 6 hrs. The reaction mixture was treated in the same procedure as in Example 8 to give methyl 2-ethoxyimino-2-(5-formamido-1,2,4-thiadiazole-3-yl)-acetate (syn-isomer) (3.2 g, yield: 49.6%).

Provenance & Evidence