Ammonium Hydroxide → HCID 178497936, compound

HRID 965436Notes

Reaction equation

HRID 965436 reaction equation
[C:1]([N:3]=[C:4]([NH:7][C:8]1[CH:9]=[C:10]([CH:15]=[CH:16][CH:17]=1)[C:11]([O:13][CH3:14])=[O:12])SC)#[N:2].[OH-].[NH4+:19]>C(O)C>[NH2:19][C:4]([NH:7][C:8]1[CH:9]=[C:10]([CH:15]=[CH:16][CH:17]=1)[C:11]([O:13][CH3:14])=[O:12])=[N:3][C:1]#[N:2]

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 178497930HCID 178497930, compound

Product 1

HCID 178497936HCID 178497936, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
70 °C

Procedure

A mixture of the compound produced in Step A (1.0 g) and ammonium hydroxide (2 ml) in ethanol (20 ml) was heated at 70° C. in a sealed tube for 3.5 hours. The reaction mixture was cooled to room temperature and reduced to half its volume. After standing overnight at room temperature a white solid was obtained, which was isolated by filtration and washed with methanol. This afforded the above compound (389 mg) as a white solid.

Workup

  1. temperatureThe reaction mixture was cooled to room temperature
  2. customa white solid was obtained
  3. customwhich was isolated by filtration
  4. washwashed with methanol

Sources & evidence

ORD record
ord-6b70c0593b414f67944dd44c2546e2f1
Source dataset
uspto-grants-1998_06
Patent number
US05773644

Reaction notes

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