HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 57139336, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Cyclohexanecarboxaldehyde | HCID 16275 | — |
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 5-Chlorooxindole | HCID 152801 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 57139336 | HCID 57139336 | 67.3% |
Reaction Steps
A solution of 10 g of 5-chloro-1,3-dihydroindol-2-one, 6.18 g of cyclohexanecarboxaldehyde and 4.93 ml of pyrrolidine in 250 ml of toluene is refluxed for 1 hour, the water formed being removed by means of a Dean-Stark apparatus. The reaction mixture is concentrated to about 90 ml and left to crystallize. The crystalline product formed is filtered off and washed with toluene and then with iso ether to give 9.7 g of the expected product after recrystallization from toluene. M.p.=203°-204° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05773612 |
| Source dataset | uspto-grants-1998_06 |
| ORD ID | ord-f546546e23aa4039912f3ae13550b381 |
| Source note | uspto-grants-1998_06 |