HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Nitrobenzenesulfonyl chloride → 5-Chloro-3-(2-chlorophenyl)-1,3-dihydro-3-(methylamino)-1-(4-nitrobenzenesulfonyl)indol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Nitrobenzenesulfonyl chloride | HCID 7404 | — |
| Reactant | 5-Chloro-3-(2-chlorophenyl)-1,3-dihydro-3-(methylamino)indol-2-one | HCID 19076510 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 5-Chloro-3-(2-chlorophenyl)-1,3-dihydro-3-(methylamino)-1-(4-nitrobenzenesulfonyl)indol-2-one | HCID 19076581 | 68.9% |
Reaction Steps
This compound is prepared according to the procedure described in EXAMPLE 11 from 7.03 g of 5-chloro-3-(2-chlorophenyl)-1,3-dihydro-3-(methylamino)-indol-2-one and 5.73 g of 4-nitrobenzenesulfonyl chloride. Chromatography on silica using DCM as the eluent gives 7.76 g of the expected product after crystallization from iso ether. M.p.=220°-221° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05773612 |
| Source dataset | uspto-grants-1998_06 |
| ORD ID | ord-cb68ebdf2f13432ab5e06d2edf97b4cc |
| Source note | uspto-grants-1998_06 |