HRID965594

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2759828

Methyl 4-(bromomethyl)-3-methoxybenzoate

C10H11BrO3

结构：CC(C)(C)OC(=O)NCCCCCNC1(c2ccccc2Cl)C(=O)Nc2ccc(Cl)cc21

HCID19076501

未命名化合物

PRODUCTS

生成物

结构：COC(=O)c1ccc(CN2C(=O)C(NCCCCCNC(=O)OC(C)(C)C)(c3ccccc3Cl)c3cc(Cl)ccc32)c(OC)c1

HCID19076457

未命名化合物

收率 75%

PROCEDURE

实验过程

This compound is prepared according to the procedure described in EXAMPLE 89 from 2 g of 3-[[5-(tert-butoxycarbonylamino)pentyl]amino]-5-chloro-3-(2-chlorophenyl)-1,3-dihydroindol-2-one and 1.19 g of methyl 4-bromomethyl-3-methoxybenzoate. 2.06 g of the expected product are obtained.

WORKUP

后处理

customThis compound is prepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-cda65e916c2141719b0e7c0da23be178
来源数据集: uspto-grants-1998_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05773612
来源说明: uspto-grants-1998_06

反应 SMILES

[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][NH:14][C:15]1([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=2[Cl:32])[C:23]2[C:18](=[CH:19][CH:20]=[C:21]([Cl:24])[CH:22]=2)[NH:17][C:16]1=[O:25])=[O:7])([CH3:4])([CH3:3])[CH3:2].Br[CH2:34][C:35]1[CH:44]=[CH:43][C:38]([C:39]([O:41][CH3:42])=[O:40])=[CH:37][C:36]=1[O:45][CH3:46]>>[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][NH:14][C:15]1([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=2[Cl:32])[C:23]2[C:18](=[CH:19][CH:20]=[C:21]([Cl:24])[CH:22]=2)[N:17]([CH2:34][C:35]2[CH:44]=[CH:43][C:38]([C:39]([O:41][CH3:42])=[O:40])=[CH:37][C:36]=2[O:45][CH3:46])[C:16]1=[O:25])=[O:7])([CH3:4])([CH3:2])[CH3:3]