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Methyl 4-(bromomethyl)-3-methoxybenzoate → Methyl 4-[[3-[[5-(tert-butoxycarbonylamino)pentyl]amino]-5-chloro-3-(2-chlorophenyl)-2,3-dihydro-2-oxoindol-1-yl]methyl]-3-methoxybenzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl 4-(bromomethyl)-3-methoxybenzoate | HCID 2759828 | — |
| 反応物 | 3-[[5-(Tert-butoxycarbonylamino)pentyl]amino]-5-chloro-3-(2-chlorophenyl)-1,3-dihydroindol-2-one | HCID 19076501 | — |
| 生成物 | Methyl 4-[[3-[[5-(tert-butoxycarbonylamino)pentyl]amino]-5-chloro-3-(2-chlorophenyl)-2,3-dihydro-2-oxoindol-1-yl]methyl]-3-methoxybenzoate | HCID 19076457 | 75% |
反応手順
This compound is prepared according to the procedure described in EXAMPLE 89 from 2 g of 3-[[5-(tert-butoxycarbonylamino)pentyl]amino]-5-chloro-3-(2-chlorophenyl)-1,3-dihydroindol-2-one and 1.19 g of methyl 4-bromomethyl-3-methoxybenzoate. 2.06 g of the expected product are obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05773612 |
| 出典データセット | uspto-grants-1998_06 |
| ORD ID | ord-cda65e916c2141719b0e7c0da23be178 |
| 出典メモ | uspto-grants-1998_06 |