Morpholine, 4-(chloroacetyl)- → 5-AMINO-6-CHLORO-2-ETHYL-N-{[1-(2-MORPHOLIN-4-YL-2-OXOETHYL)PIPERIDIN-4-YL]METHYL}IMIDAZO[1,2-a]PYRIDINE-8-CARBOXAMIDE

HRID 965805Notes

Reaction equation

HRID 965805 reaction equation
[NH2:1][C:2]1[N:7]2[CH:8]=[C:9]([CH2:11][CH3:12])[N:10]=[C:6]2[C:5]([C:13]([NH:15][CH2:16][CH:17]2[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]2)=[O:14])=[CH:4][C:3]=1[Cl:23].Cl[CH2:25][C:26]([N:28]1[CH2:33][CH2:32][O:31][CH2:30][CH2:29]1)=[O:27]>>[NH2:1][C:2]1[N:7]2[CH:8]=[C:9]([CH2:11][CH3:12])[N:10]=[C:6]2[C:5]([C:13]([NH:15][CH2:16][CH:17]2[CH2:22][CH2:21][N:20]([CH2:25][C:26]([N:28]3[CH2:33][CH2:32][O:31][CH2:30][CH2:29]3)=[O:27])[CH2:19][CH2:18]2)=[O:14])=[CH:4][C:3]=1[Cl:23]

Participants

3

Reactant 2

HCID 74040Morpholine, 4-(chloroacetyl)-HCID 99496125-amino-6-chloro-2-ethyl-N-(piperidin-4-ylmethyl)imidazo[1,2-a]pyridine-8-carboxamide

Product 1

HCID 100500125-AMINO-6-CHLORO-2-ETHYL-N-{[1-(2-MORPHOLIN-4-YL-2-OXOETHYL)PIPERIDIN-4-YL]METHYL}IMIDAZO[1,2-a]PYRIDINE-8-CARBOXAMIDE

Procedure

The title compound was prepared according to the procedure described in the step 5 of Example 4 from 5-amino-6-chloro-2-ethyl-N-(piperidin-4-ylmethyl)imidazo[1,2-a]pyridine-8-carboxamide (Example 4, Step 4) and 4-(chloroacetyl)morpholine (B. G. Hazra; V. S. Pore; S. P. Maybhate, Org. Prep. Proced. Int., 1989, 21, 355-8).

Sources & evidence

ORD record
ord-3d6bcab2c20543699889dbf9a1d11eb8
Source dataset
uspto-grants-2005_10
Patent number
US06951867B2

Reaction notes

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